CHENE4750 The Genome and the Cell

The utility of genomic information lies in its capacity to predict the behavior of living cells in physiological, developmental, and pathological situations. The effect of variations in genome structure between individuals within a species, including those deemed healthy or diseased, and among species, can be inferred statistically by comparisons of sequences with behaviors, and mechanistically, by studying the action of molecules whose structure is encoded within the genome. This course examines known mechanisms that elucidate the combined effect of environmental stimulation and genetic makeup on the behavior of cells in homeostasis, disease states, and during development, and includes assessments of the probable effect of these behaviors on the whole organism. Quantitative models of gene translation and intracellular signal transduction will be used to illustrate switching of intracellular processes, transient and permanent gene activation, and cell commitment, development, and death.

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