BMCHE4810 Artificial Organs

Analysis and design of replacements for the heart, kidneys, and lungs. Specification and realization of structures for artificial organ systems. Understand the individual and synergistic function of the major natural ("internal") organs. Understand the major organ replacement systems currently available. Understand the opportunities for, and the major problems associated with, replacing failed organs Cardiovascular system Renal system Pulmonary system (Lung disease; heart-lung bypass) Hepatic system Endocrine system Neural prostheses (Muscular-skeletal prostheses) Identify basic engineering approaches to organ replacement: Functional specification; Locational issues; Device-organism interface (impedance matching); blood access; alternatives to blood Temporal activity --intermittency and control; Energy issues; Biocompatibility and bioactivity Materials: Functional specifications Hemocompatibility Biocompatibility Hybrid system materials Design approaches: Conceptual specification Initial modeling (multi-scale approaches) Modeling during development; Allowance for subject variability Manufacturing Issues: Cleanliness, particle elimination Sterilization Smart packaging Regulatory (FDA) concerns: Animal testing Clinical testing . Specific systems to be studied in detail: Blood vessel replacements; ventricular assist devices; cardiopulmonary bypass systems; hemodialysis systems. Specific engineering/physical chemical concepts to be reviewed and applied: Convective and diffusive transport; phase and ligand-solution equilibria; serial rate processes; transport-coupled enzyme kinetics

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